Objective
To produce the first pilot study of a NICE model using DICE simulation
Model Type and Methods
The model is an Excel-based discretely integrated condition-event (DICE) simulation.
Model Description
This... Read more ⟶
In this paper, an alternative, more natural, way to model clinical reality – discrete event simulation – is presented and its application is illustrated with a real world example.
... Read more ⟶
Provides consensus-based guidelines on the application of DES in a health care setting, covering the range of issues to which DES can be applied.
... Read more ⟶
An economic evaluation for France of bDMARD sequences for treatment of moderate-to-severe RA after inadequate response or intolerance to conventional DMARDs (eg, methotrexate).
... Read more ⟶
Combining the 'recipe' idea with a common software like Excel, and the need to 'cook' all kinds of different model types (Markov, micro-simulation, DES, partitioned survival), leads to the DICE method... Read more ⟶
Using an example of an existing model constructed by the National Institute for Health and Care Excellence (NICE) to inform a real health technology assessment, this study seeks to demonstrate how a discretely... Read more ⟶
Discretely integrated condition event (DICE) simulation is proposed as a unifying approach that has been deliberately designed to meet the modeling requirements in a straightforward transparent way, without... Read more ⟶
Discretely integrated condition event (DICE) simulation provides for both aspects that persist over time ('conditions') and for those happening at a point in time ('events'). A Markov model can be specified... Read more ⟶
This project has received funding from the European Union’s Horizon 2020
FILES FOR DOWNLOAD
Engine & templates
Template: TTE model
Template to get started with building a TTE model in DICE ... Read more ⟶
Template: Microsim model
Template to get started with building a Microsim model in DICE ... Read more ⟶
Template: Markov model
Template to get started with building a Markov model in DICE ... Read more ⟶
Template: Any type
Template to get started with building a DICE model (any type) ... Read more ⟶
DICE execution engine
DICE execution engine containing all the required macros (version 1.8h) ... Read more ⟶
Documents
Uncertainty worksheet
Explanation of the uncertainty worksheet ... Read more ⟶
DICE simulation manual
User manual for the DICE engine and templates ... Read more ⟶
Versions, international and language issues
Instructions for dealing with decimal delimiter and other language issues ... Read more ⟶
Training
DICE Training Video 8: Introduction to Excel for DICE
... Read more ⟶
DICE Training Video 7: How is time handled in DICE?
... Read more ⟶
DICE Training Video 6: Elements of DICE design
... Read more ⟶
DICE Training Video 5: What are DICE conditions and events?
... Read more ⟶
DICE Training Video 4: How are inputs and outputs treated in DICE?
... Read more ⟶
DICE Training Video 3: An overview of a DICE model
... Read more ⟶
DICE Training Video 2: How does DICE work?
... Read more ⟶
DICE Training Video 1: What is DICE?
... Read more ⟶
DICE Training Videos (All)
Access all 8 training videos ... Read more ⟶
Build guide: TTE model
Step-by-step build guide for the TTE model example ... Read more ⟶
Build guide: Markov models
Step-by-step build guide for the Markov model example ... Read more ⟶
Example models
DICE Model of COVID-19 Hospital Resource Use
Model created to simulate the use of hospital resources during COVID-19 ... Read more ⟶
DICE model:TTE
Fully built DICE TTE model ... Read more ⟶
DICE model: Microsimulation
Fully built DICE Microsimulation model ... Read more ⟶
DICE model: Markov
Fully built DICE Markov model ... Read more ⟶
iMPACT HTA Breast Cancer Prevention DICE Model
Objective To produce the first pilot study of a NICE model using DICE simulation Model Type and Methods The model is an Excel-based discretely integrated condition-event (DICE) simulation. Model Description This... Read more ⟶
Articles
Discrete event simulation: the preferred technique for health economic evaluations?
Discrete event simulation should be preferred to cohort Markov models for economic evaluations in health care. ... Read more ⟶
Advantages and disadvantages of discrete-event simulation for health economic analyses
... Read more ⟶
Pharmacoeconomic analyses using discrete event simulation
In this paper, an alternative, more natural, way to model clinical reality – discrete event simulation – is presented and its application is illustrated with a real world example. ... Read more ⟶
Improving transparency in decision models: Current issues and potential solutions
... Read more ⟶
Modeling using discrete event simulation: a report of the ISPOR-SMDM Modeling Good Research Practices Task Force–4
Provides consensus-based guidelines on the application of DES in a health care setting, covering the range of issues to which DES can be applied. ... Read more ⟶
Trusting the results of model-based economic analyses: Is there a pragmatic validation solution?
Outline the requirements for improvement and pragmatic solutions to the problem of inadequate validation. ... Read more ⟶
Economic evaluation of sequences of biological treatments for patients with moderate-to-severe Rheumatoid Arthritis and inadequate response or intolerance to Methotrexate in France
An economic evaluation for France of bDMARD sequences for treatment of moderate-to-severe RA after inadequate response or intolerance to conventional DMARDs (eg, methotrexate). ... Read more ⟶
Cooking up a transparent model following a DICE recipe
Combining the 'recipe' idea with a common software like Excel, and the need to 'cook' all kinds of different model types (Markov, micro-simulation, DES, partitioned survival), leads to the DICE method... Read more ⟶
Leveraging DICE (Discretely-Integrated Condition Event) simulation to simplify the design and implementation of hybrid models
Using an example of an existing model constructed by the National Institute for Health and Care Excellence (NICE) to inform a real health technology assessment, this study seeks to demonstrate how a discretely... Read more ⟶
Discretely Integrated Condition Event (DICE) simulation for pharmacoeconomics
Discretely integrated condition event (DICE) simulation is proposed as a unifying approach that has been deliberately designed to meet the modeling requirements in a straightforward transparent way, without... Read more ⟶
Adding events to a Markov Model using DICE simulation
Discretely integrated condition event (DICE) simulation provides for both aspects that persist over time ('conditions') and for those happening at a point in time ('events'). A Markov model can be specified... Read more ⟶
Validation of a DICE simulation against a Discrete Event Simulation implemented entirely in code
To assess if a DICE simulation provides equivalent results to an existing discrete event simulation, a comparison was undertaken ... Read more ⟶